Endocrine Abstracts

Introduction: In humans bacterial lipopolysaccharide (LPS/endotoxin) causes chronic low-grade and acute inflammatory responses, which decrease insulin sensitivity and may lead to chronic type 2 diabetes and acute stress diabetes. Systemic LPS invariably generates cytokine release, which triggers release of anti-insulin stress hormones and it is not known whether insulin resistance is secondary to stress hormones or LPS per se. Our study was designed to test whether local place...